Browsing Volume 6 Issue 2, 2015 by Issue Date
Now showing items 1-20 of 24
-
In vivo studies: multi-disciplinary action of Digitalis purpurea Linn. extract in rabbits
(JK Welfare & Pharmascope Foundation, 2015-04-20)In continuation to our studies on Digitalis purpurea Linn., now we report that on oral introduction of its extract in low concentration (25mg/ml) for 90 days in rabbits (male & female), most of the blood parameters were ... -
Hepato protective activity of Cucumissativus L.
(JK Welfare & Pharmascope Foundation, 2015-04-20)Liver disorder is one of the familiar health troubles and it is exposed to several category of xenobiotics and therapeutic agents. The present research was designed to investigate the possible Hepatoprotective effect of ... -
A rapid UPLC-UV method development and validation for the quantitative determination of Formaldehyde using derivatization technique
(JK Welfare & Pharmascope Foundation, 2015-04-20)The Objective of the current study was to develop and validate a Rapid UPLC-UV method for the quantitation of Formaldehyde. Formaldehyde (HCHO) is reacted with 2,4-dinitrophenylhydrazine (DNPH) to form a Schiff base ... -
Chemical composition and in-vitro anti-arthritic activity of essential oils extracted from the leaves of Lagerstroemia speciosa
(JK Welfare & Pharmascope Foundation, 2015-04-20)The study was designed to determine the chemical composition, and in-vitro anti-arthritic activity of the essential oils from the fresh and dry leaves of Lagerstroemia speciosa (L.speciosa). The essential oils from the ... -
A new RP-HPLC method development and validation for simultaneous estimation of lamotrigine and zonisamide in pharmaceutical tablet dosage formulations
(JK Welfare & Pharmascope Foundation, 2015-04-20)A simple, specific, rapid, accurate and sensitive RP-HPLC method was developed and validated for the simultaneous estimation of Lamotrigine and Zonisamide in bulk drug and pharmaceutical tablet dosage form. The separation ... -
Formulation and evaluation of Trospium chloride Microspheres for sustained drug delivery
(JK Welfare & Pharmascope Foundation, 2015-04-20)The objective of the present study was to prepare and evaluate microspheres for the sustained release of Trospium Chloride by using various ratio of 1.5%w/v chitosan polymer, 2.5% w/v chitosan polymer, 3.5%w/v chitosan ... -
Formulation development and evaluation of floating drug delivery of Anti-diabetic drug
(JK Welfare & Pharmascope Foundation, 2015-04-20)Polymer concentration and gas generating agents were effect on the floating drug release from floating tablets. To utilize the dissolution data and gain insight into the drug release mechanism from polymer floating tablet. ... -
Design, synthesis, characterization and anti-inflammatory activity of some novel Benzimidazole derivatives
(JK Welfare & Pharmascope Foundation, 2015-04-20)A novel series of benzimidazole derivatives were synthesized through modifying the N-1 hydrogen of 2-substituted benzimidazoles with primary and/or secondary amines in ethanol yielded the corresponding N-Mannich bases ... -
Stability indicating method for simultaneous determination of polar and non-polar related compounds of Zidovudine in drug substance and drug product tablet form
(JK Welfare & Pharmascope Foundation, 2015-04-20)A Simple, rapid and sensitive method has been developed and validated for the determination of polar and non-polar related compounds of Zidovudine (ZVD) in drug substance and drug product. Efficient chromatographic separation ... -
Isolation of Terflavin B from fruits of Terminalia chebula retz
(JK Welfare & Pharmascope Foundation, 2015-04-20)Terminalia chebula Retz is known as “Haritaki” belong to the family Combretaceae. It is also known as Mother of all healings. Literature survey reveals that it have antifungal, antibacterial, anticarcinogenic, antidiabetic, ... -
Evaluation of antioxidant and anticancer activities of Orthosiphon aristatus (Blume)
(JK Welfare & Pharmascope Foundation, 2015-04-20)Orthosiphon aristatus (Blume) Miq. (Lamiaceae) is traditionally used to treat various ailments like diabetes mellitus, hypertension, rheumatism, tonsillitis, menstrual disorders and those affecting the urinary tract. The ... -
Formulation and evaluation of Abacavir microspheres
(JK Welfare & Pharmascope Foundation, 2015-04-20)The objective of present study was to encapsulate the anti-retroviral drug in various polymers in order to provide the sustained release and to minimize or reduce the dose dependent side effects as well as to improve the ... -
Dissolution enhancement of Tacrolimus by surface solid-dispersion technique
(JK Welfare & Pharmascope Foundation, 2015-04-20)The work was aimed to increase the dissolution rate of tacrolimus by surface solid dispersion technique. being insoluble in water, tacrolimus exhibits very low drug dissolution profiles and hence it was planned to modify ... -
Chronic alcohol consumption: Increases the liver marker enzymes and hepatic damage on the albino Wister rat liver
(JK Welfare & Pharmascope Foundation, 2015-04-20)To investigate the effect of ethanol induced liver toxicity in male Wister albino rats. The liver toxicity was induced by the chronic administration of ethanol to the animals at the 20%v/v, 10%v/v respectively for 28 days ... -
Antidandruff activity of Eclipta alba (l.) Hassk. and Lippia nodiflora linn
(JK Welfare & Pharmascope Foundation, 2015-04-20)This experiment was subjected to investigate anti dandruff properties of ethanolic extract and isolated compound of Eclipta alba and Lippia nodiflora. The plant specimen for the proposed study E. alba and L. nodiflora was ... -
Selection of excipients for the formulation of Ceftriaxone sodium loaded chitosan Nanoparticle through drug - excipient compatibility testing
(JK Welfare & Pharmascope Foundation, 2015-04-20)Ceftriaxone (CFTX) sodium is a 3rd generation semisynthetic antibiotic that can effectively treat several types of bacterial infections. The best formulation is considered appropriate when no interactions between drug-excipient ... -
Formulation and evaluation of gastro-retentive drug delivery system of losar-tan potassium by using raft-forming approach
(JK Welfare & Pharmascope Foundation, 2015-04-20)Losartan potassium is angiotensin type-II receptor antagonist, used for the treatment anti hypertension. The purpose of this investigation is to improve bioavailability, gastro residence time and to reduce frequency of ... -
Formulation and evaluation of pioglitazone hydrochloride pellets
(JK Welfare & Pharmascope Foundation, 2015-04-20)The aim of the present study was to formulate and evaluate Pioglitazone hydrochloride pellets. The Pioglitazone hydrochloride immediate and controlled release pellets were prepared by solution/suspension layering technique ... -
A novel combination therapy for treating breast cancer: Preclinical proof-of-concept
(JK Welfare & Pharmascope Foundation, 2015-04-20)Combining the anticancer drugs at their sub optimal doses with other non-cytotoxic agents possessing potential anticancer property is a promising strategy for effective anticancer treatment with reduced toxicity. In the ... -
An insight of spondias mangifera willd: an underutilized medicinal plant with immense nutraceutical and therapeutic potentials
(JK Welfare & Pharmascope Foundation, 2015-04-20)Spondias mangifera, is best known for its fruits in Indo-Malaysia region. The fruit contains about 25 percent juicy and edible pulp. The pulp is used as a common ingredient in culinary preparations like condiments, curries, ...