Browsing Volume 3 Issue 2, 2012 by Issue Date
Now showing items 1-20 of 28
-
Modulating effect of Andrographolide on cell surface glycoconjugates status during 7,12-dimethylbenz(a) anthracene induced hamster buccal pouch carcinogenesis
(JK Welfare & Pharmascope Foundation, 2012-04-25)Cell surface glycoconjugates play an important role in pinocytosis, cell differentiation, intra cellular recognition, cell adhesion and tumorigenesis. Aim of the present study was to investigate the protective effect of ... -
Formulation and in vitro comparative evaluation of orodispersible tablets of Granisetron hydrochloride
(JK Welfare & Pharmascope Foundation, 2012-04-25)In the present work, an attempt has been made to formulate oral dispersible tablets of granisetron HCl by three different methods. Conventional tabletting procedure was followed for the preparation of tablets. Nine batches ... -
Synthesis, spectral, thermal and antimicrobial studies of some transition metal complexes containing 2-thiophenecarboxaldehyde moiety
(JK Welfare & Pharmascope Foundation, 2012-04-25)Some Schiff base metal complexes of Co(II), Ni(II) and Cu(II) derived from 2-thiophenecarboxaldehyde with 2-imidodicarbonic diamide (TID) 2-chloro-4-nitroaniline (TCA) have been synthesized and characterized by elemental ... -
Floristic analysis and phytosociological studies on trees of Perumal Malai hill, Salem, Tamil Nadu
(JK Welfare & Pharmascope Foundation, 2012-04-25)The study area Perumalmalai is situated in Southern Eastern Ghats. It is located between 78° 10' Longitude in East and 110° 70’ Latitude in North. The flora enriched with 47 families, 89 genera and 106 species of angiosperm. ... -
The influence of polyethylene glycol structure on the conjugation of recombinant human interferon α2b overproduced using synthetic gene in E.coli
(JK Welfare & Pharmascope Foundation, 2012-04-25)Interferon α2b (IFNα2b) is a cytokine which has antiviral, antiproliveration and immunomudulator activities. IFN α2b has been used as a drug for treatment of hepatitis B and C infections. However, the use of this protein ... -
Comparative review on conventional advanced occular drug delivery system
(JK Welfare & Pharmascope Foundation, 2012-04-25)Eye diseases are commonly encountered in a day to day life, which are most interesting and challenging for scientists. A newly development and particulate vesicular systems like liposomes, pharmacosomes and discomes are ... -
Development and validation methods for the estimation of Clopidogrel in bulk and pharmaceutical dosage forms
(JK Welfare & Pharmascope Foundation, 2012-04-25)The present research work discussed Development and validation of HPLC method for the estimation of clopidogrel in bulk and pharmaceutical dosage forms, which is based on the measurement of absorption maxima at 217 nm. ... -
Pharmacophore Modeling and 3D QSAR analysis of flavonoids and congeners active against A549 cell line
(JK Welfare & Pharmascope Foundation, 2012-04-25)In our present study we have developed a ligand based 3D QSAR of 27 flavonoids and congeners active against human lung cancer cell line (A549) using the Phase module of Schrödinger suit. A five feature pharmacophore (AAARR) ... -
Phytochemical evaluation and study of in vitro antioxidant potential of ethanolic and aqueous extracts of Amorphophallus campanulatus: a popular tuber of West Bengal
(JK Welfare & Pharmascope Foundation, 2012-04-25)The use of herbal medicines worldwide had provided an excellent opportunity to India to look for therapeutic compounds from our ancient system of therapy, Ayurveda, which can be utilized for development of new drug. ... -
Design and ex-vivo evaluation of adhesive matrix type transdermal patch of buspirone hydrochloride
(JK Welfare & Pharmascope Foundation, 2012-04-25)The present work was intended to design alternative dosage form to the conventional tablets of the Buspirone hydrochloride (BH); as about 96% drug is metabolized during its first pass by oral route. An adhesive matrix ... -
Evaluation of change in pH, Osmolarity upon change in concentration of mannitol and sodium acetate anhydrous at fixed concentration of gemcitabine hydrochloride
(JK Welfare & Pharmascope Foundation, 2012-04-25)The experimental objective was to evaluate change in pH, Osmolarity upon change in concentration of Mannitol and Sodium acetate anhydrous at fixed concentration of Gemcitabine hydrochloride. So the experiment was designed ... -
Antifungal activity of methanolic fractions of Alstonia scholaris against clinical isolates of Candida and other Yeast species
(JK Welfare & Pharmascope Foundation, 2012-04-25)Secondary metabolites are produced by many plants which are useful to human beings. These metabolites have been known for ages and served as potent antimicrobial agents. Alstonia scholaris (AS) is one of the most important ... -
Effect of various penetration enhancers on permeation kinetic of itraconazole for the topical drug delivery system
(JK Welfare & Pharmascope Foundation, 2012-04-25)Itraconazole (ITZ) is a synthetic triazole antifungal agent having topical and systemic efficacy against familiar fungi such as Aspergillus and other filamentous fungi. The difficulties of ITZ with oral administration like ... -
A study of evaluation of safety and efficacy of memomet, a multi herbal formulation (memomet) in the treatment of behavioural disorder in children
(JK Welfare & Pharmascope Foundation, 2012-04-25)This study shows the efficacy of Memomet in the treatment of ADHD in children. Total 86 patients were recruited in the study. There were 56 children in the treated group and 30 in placebo treated group. The children were ... -
In vitro antibacterial activities study of norfloxacin containing mucoadhesive suspensions
(JK Welfare & Pharmascope Foundation, 2012-04-25)To study the in vitro antibacterial properties of mucoadhesive suspensions containing Norfloxacin, three different formulations were prepared by using three polymers, such as Hydroxypropyl methylcellulose (HPMC) (S₁), ... -
Formulation and evaluation of bilayer floating tablets of Diltiazem hydrochloride for bimodal release
(JK Welfare & Pharmascope Foundation, 2012-04-25)In the present investigation concern, the formulation and evaluation of bilayer floating tablet of diltiazem hydrochloride which after an oral administration increase gastric residence time, to increase the bioavailability. ... -
Lupeol protects DNA damage against 7,12-dimethylbenz(a)anthracene induced genotoxicity
(JK Welfare & Pharmascope Foundation, 2012-04-25)The present study has investigated the protective effect of lupeol on 7,12-dimethylbenz (a)anthracene (DMBA) induced genotoxicity in the bone marrow cells of golden Syrian hamsters. DNA damage was assessed in the bone ... -
Design and evaluation of three layer matrix tablet of Losartan potassium capped with Eudragit and HPMC combination
(JK Welfare & Pharmascope Foundation, 2012-04-25)In the present investigation concern the formulation and evaluation of trilayer matrix tablets of losartan potassium (LP). Losartan potassium is an angiotensin-II receptor antagonist drug used mainly to treat high blood ... -
Formulation and evaluation of Rifampicin loaded poly-ε-caprolactone nano-particles using 3² factorial design
(JK Welfare & Pharmascope Foundation, 2012-04-25)The objective of this work was to apply the response surface approach in the development of Rifampicin nanoparticle with poly-ε-caprolactone (PCL). Experiments were performed according to a 3² factorial design to evaluate ... -
Formulation and physicochemical evaluation of Indomethacin transdermal patches
(JK Welfare & Pharmascope Foundation, 2012-04-25)Indomethacin is a NSAID available for several decades, highly effective against any condition of pain. In this study drug dispersion with different polymers like hydroxyl propyl methyl cellulose (HPMC), polyvinyl pyrolidine ...