Effect of caloric vestibular stimulation in a paraquat-induced parkinsonian mouse model

Abstract

The present study was taken up to observe the effect of caloric vestibular stimulation on brain neurochemicals in a paraquat-induced Parkinsonian mouse model. 24 healthy, adult male Swiss albino mice with body weight ranging between 25-40 g were used in the study. The middle ear cavity of the mice was irrigated with hot (40oC) water. 0.5 ml of water was taken in 5 ml syringe with the needle removed. The ear was irrigated with water drop by drop, using the syringe. Gently the earlobe of mice was shaken. The procedure was continued with the other ear. Acetylcholine, dopamine, serotonin and GABA were estimated. The results of the present study show a positive impact of vestibular stimulation in the management of the Parkinson's disease. Further detailed research is required to understand the mechanism of action behind the performance of vestibular stimulation and could be adopted in the management of Parkinson's disease.