Synthesis, characterisation and antibacterial evaluation of some novel 1-phenyl-1h-tetrazole-5-thiol derivatives
Athraa H Mekky
Sajida M Thamir
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The aim of the study is to synthesise and. Characterize — some novel, "tetrazole., -5-thiol” derivatives. Firstly, the “1-phenyl-1H7-tetrazole-5-thiol” (A₁) has been., synthesised by the reaction of phenylisothiocyanate with NaN₃ in water as a solvent. Secondly, the tetrazole-5-thiol derivatives (A₂-A₄) were synthesised by the alkylation reaction of the compound (A₁) with chloroacetone, phenacyl bromide and chloromethyl acetate respectively. The resulted percentage yield was relatively high (92%, %95, %90 respectively). Compound (A₅) was synthesised by the reaction of ethyl acetate tetrazole derivative (A₄) with hydrazine. Moreover, the derivatives (A₆-A₁₁) were synthesised by the reaction of the (A₅) with various substituted aromatic aldehydes. Moreover, compounds (A₁₂-A₁₃) have been synthesised by the cyclization reaction of compound A₅ with acetylacetone and phenyl acetylacetone respectively. The produced compounds have been identified by IR, ¹³C-NMR and ¹H-NMR Spectroscopy, and the quantities of various of the physical data (melting point, the shape of crystal and color). Finally, the compounds were examined for their biological activities alongside two kinds of bacteria (E. Coli and Staphylococcus aureus). Compounds A₂, A₄, A₈, A₁₁ and A₁₃ showed the highest inhibition activity against E. Coli. Compounds A₂, A₉, A₁₀ and A₁₃ showed the maximum activity against Staphylococcus aureus.