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dc.contributor.authorFahad Khan
dc.contributor.authorPratibha Pandey
dc.contributor.authorRashmi Mishra
dc.contributor.authorNiraj Kumar Jha
dc.contributor.authorShweta Sharma
dc.date.accessioned2021-10-13T10:48:42Z
dc.date.available2021-10-13T10:48:42Z
dc.date.issued2019-04-14
dc.identifier.issn0975-7538
dc.identifier.urihttp://scopeindex.org/handle/sc/1279
dc.description.abstractCancer kills millions of people worldwide every year. The main form of treatment at this point is chemotherapy, which comprises of systemic drug delivery so that they can kill the cancerous cells more effectively. But most of these drugs cause severe side effects in patients and, therefore there is a strong need to focus on identifying natural compounds as a potent phytoinhibitors using various in silico and in vitro approaches. Natural compounds pose low toxicity, hence render them to be an excellent alternative to the basis for the development of new anti-cancerous drugs. Our study considers an effective therapeutic target, Jab1 (c-Jun activation domain-binding protein-1) or a c-Jun coactivator, which has been implicated in multiple protein interactions that play a significant role in various stages of carcinogenesis. Hence we have performed screening of 1500 natural compounds having anticancerous activity by applying various in silico approaches including Lipinski rule of five, ADME, and various Molecular Docking tools. In this study, we have identified two potent phytoinhibitors against Jab1 which needs to be further validated through in vitro approaches.en_US
dc.language.isoenen_US
dc.publisherJK Welfare & Pharmascope Foundationen_US
dc.relation.ispartofseriesVolume 10;Issue 2
dc.subjectCanceren_US
dc.subjectSignal transduction pathwaysen_US
dc.subjectNatural Compoundsen_US
dc.subjectJab1en_US
dc.subjectin silicoen_US
dc.subjectChemotherapyen_US
dc.subjectChemopreventive compoundsen_US
dc.titleAn in silico study on plant-derived inhibitors against a prognostic Biomarker, Jab1en_US
dc.typeArticleen_US


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